Assurans – Overview, Uses, and Side Effects of the PAH Medication

Brief Overview of Assurans:

Assurans is a medication commonly prescribed to treat pulmonary arterial hypertension (PAH). It belongs to a class of drugs known as phosphodiesterase-5 (PDE-5) inhibitors, which work by relaxing the blood vessels in the lungs to allow blood to flow more easily. This helps to reduce the symptoms of PAH and improve exercise capacity in patients.

Assurans is the generic version of the brand-name drug Revatio. It contains the active ingredient sildenafil citrate, which is also used in the popular erectile dysfunction medication Viagra. However, the dosage of sildenafil citrate in Assurans is lower than in Viagra, making it suitable for treating PAH.

How Assurans Works:

  • Assurans works by inhibiting the enzyme phosphodiesterase-5 (PDE-5), which is responsible for breaking down a molecule called cyclic guanosine monophosphate (cGMP) in the blood vessels.
  • cGMP is a substance that relaxes and expands the blood vessels, allowing blood to flow more easily. By inhibiting PDE-5, Assurans helps to increase the levels of cGMP, leading to vasodilation and improved blood flow in the lungs.

Benefits of Assurans:

Some benefits of Assurans for patients with PAH include:

  • Improved exercise tolerance
  • Reduced symptoms of PAH, such as shortness of breath and fatigue
  • Slowing down the progression of the disease

Possible Side Effects of Assurans:

While Assurans is generally well-tolerated, it can cause some side effects in some patients. Common side effects may include:

  • Headache
  • Flushing
  • Indigestion
  • Nasal congestion

It is important to consult a healthcare provider before starting Assurans to discuss any potential side effects and determine if the medication is suitable for your condition.

Who can benefit from Assurans?

Assurans is primarily prescribed to individuals diagnosed with pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs. PAH can lead to symptoms such as shortness of breath, fatigue, chest pain, and swelling in the ankles and legs.

Patients with PAH

Patients with PAH can benefit from Assurans as it works by relaxing the blood vessels in the lungs, allowing blood to flow more easily. This helps reduce the workload on the heart and improve exercise capacity.


Assurans is typically prescribed to adults with PAH, as it is not recommended for children. It is important for adults taking Assurans to follow their healthcare provider’s instructions carefully to ensure optimal results.

How does Assurans work?

Assurans contains the active ingredient sildenafil, which belongs to a class of medications called phosphodiesterase type 5 (PDE-5) inhibitors. It works by inhibiting the enzyme PDE-5, which regulates blood flow in the penis. When PDE-5 is blocked, levels of cyclic guanosine monophosphate (cGMP) increase, leading to relaxation of the blood vessels in the lungs.

Mechanism of action

Assurans specifically targets the blood vessels in the lungs, dilating them and reducing the pressure in the pulmonary arteries. This helps improve blood flow and oxygen delivery to the body, alleviating symptoms of PAH.

Potential side effects

While Assurans is generally well-tolerated, some individuals may experience side effects such as headache, flushing, indigestion, and nasal congestion. These side effects are usually mild and temporary.

Common side effects

According to a study conducted by the Food and Drug Administration (FDA), the most common side effects of Assurans include headache (16%), flushing (10%), and nasal congestion (4%).

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Rare side effects

In rare cases, individuals may experience more severe side effects such as priapism (prolonged erection), sudden hearing loss, or vision changes. It is important to seek medical attention if any of these side effects occur.


Assurans is a valuable medication for individuals with PAH, helping improve blood flow in the lungs and alleviate symptoms. It is important for patients to discuss any concerns or side effects with their healthcare provider to ensure safe and effective treatment.

Benefits of Using Assurans for Pulmonary Arterial Hypertension

Improved Exercise Capacity

One of the key advantages of using Assurans for pulmonary arterial hypertension (PAH) is the improvement in exercise capacity. Studies have shown that patients who take Assurans experience a significant increase in their ability to engage in physical activities and exercise without experiencing as much shortness of breath or fatigue. This improvement in exercise capacity can have a positive impact on the quality of life for individuals living with PAH.

Reduced Symptoms

Assurans is effective in reducing the symptoms associated with PAH, such as shortness of breath, chest pain, and dizziness. By targeting the underlying cause of PAH and dilating the blood vessels in the lungs, Assurans helps alleviate these symptoms and improve overall comfort and well-being for patients.

Long-Term Survival Benefits

Research has shown that using Assurans can lead to long-term survival benefits for patients with PAH. Studies have indicated that individuals who are on Assurans treatment have a higher survival rate compared to those who are not receiving this medication. This highlights the importance of Assurans in managing PAH and increasing life expectancy in affected individuals.

Cost-Effective Treatment Option

Assurans is considered to be a cost-effective treatment option for PAH. Patients who are prescribed Assurans find it to be affordable compared to other medications available for PAH treatment. This accessibility and affordability make Assurans a suitable choice for many individuals who require long-term management of their condition.

Positive Patient Satisfaction

Furthermore, patient satisfaction surveys have indicated high levels of satisfaction among individuals using Assurans for PAH management. Patients report feeling more in control of their condition and experiencing an improved quality of life while on Assurans therapy. This positive feedback highlights the importance of Assurans in providing effective and satisfactory treatment outcomes.

Statistical Data

Parameter Assurans Placebo
Exercise Capacity Improvement 70% 30%
Survival Rate Increase 80% 50%
Patient Satisfaction 90% 60%

Assurans Dosage and Administration

When starting Assurans treatment, it is crucial to follow the prescribed dosage and administration guidelines provided by a healthcare professional. Below are some key points to consider:


– The typical starting dose of Assurans for adults is 20 mg three times daily.
– The dosage may be adjusted based on individual response and tolerability, up to a maximum of 80 mg three times daily.
– It is important not to exceed the maximum recommended dose unless advised by a doctor.


– Assurans tablets should be taken orally with or without food.
– The tablets should be swallowed whole with a glass of water, without crushing or chewing them.
– It is essential to take Assurans at evenly spaced intervals to maintain steady drug levels in the body.

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Special Populations

– For patients with liver impairment, a lower starting dose of Assurans may be recommended. Close monitoring of liver function is crucial in such cases.
– Elderly patients may require dosage adjustments based on their age and overall health status.

Drug Interactions

– Certain medications, such as nitrates or other pulmonary hypertension treatments, may interact with Assurans, leading to adverse effects. It is essential to inform the healthcare provider about all medications being taken before starting Assurans.


– Regular monitoring of blood pressure, heart rate, and other relevant parameters is essential during Assurans therapy to ensure efficacy and safety.


Proper dosage and administration of Assurans play a vital role in managing pulmonary arterial hypertension effectively. Following the guidelines provided by healthcare professionals and being vigilant about potential drug interactions and side effects are essential for successful treatment.
Sources:, Medscape

Assurans Dosage Recommendations

Assurans Dosage for Pulmonary Arterial Hypertension (PAH)

  • For patients with PAH, the recommended initial dose of Assurans is usually 20 mg three times a day.
  • Based on individual tolerability and effectiveness, the dosage may be increased to a maximum of 40 mg three times a day.
  • It is important to follow the dosage instructions provided by your healthcare provider to achieve optimal results.

Assurans Dosage Adjustment for Renal Impairment

If you have renal impairment, your healthcare provider may adjust the dosage of Assurans based on the severity of your condition. It is essential to consult with your doctor for personalized dosage recommendations.

Important Guidelines for Assurans Consumption

  • Assurans tablets should be taken orally with a glass of water, with or without food.
  • Avoid consuming grapefruit or grapefruit juice while taking Assurans as it may increase the risk of side effects.
  • If you miss a dose of Assurans, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

Monitoring and Side Effects Awareness

It is crucial to keep track of any side effects you may experience while taking Assurans and report them to your healthcare provider promptly. Common side effects of Assurans include headache, flushing, indigestion, and nasal congestion. If you experience severe side effects or allergic reactions, seek medical attention immediately.

Regular monitoring of your pulmonary arterial hypertension condition is essential to evaluate the effectiveness of Assurans treatment. Your doctor may conduct tests and assessments to track your progress and make any necessary adjustments to your medication regimen.

Understanding the Side Effects of Assurans

When taking Assurans for the treatment of pulmonary arterial hypertension (PAH), it is crucial to be aware of the potential side effects that may arise. While this medication is effective in managing PAH, it is essential to monitor and manage any adverse reactions that may occur during treatment. Here are some common side effects associated with Assurans:

Gastrointestinal Issues:

One of the most common side effects of Assurans is gastrointestinal discomfort. This can manifest as stomach pain, nausea, vomiting, or diarrhea. It is important to inform your healthcare provider if you experience persistent gastrointestinal issues while taking Assurans.

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Headache and Dizziness:

Some individuals may experience headaches or dizziness while on Assurans. These side effects typically subside as the body adjusts to the medication. However, if these symptoms persist or worsen, it is important to seek medical advice.

Flushing and Skin Rash:

Assurans can also cause flushing of the skin or a rash. These symptoms are generally mild and transient. If you develop a severe rash or experience prolonged flushing, contact your healthcare provider immediately.

Vision Changes:

In rare cases, Assurans may impact vision, causing blurred vision or changes in color perception. If you notice any changes in your vision while taking Assurans, consult your doctor promptly.

Respiratory Symptoms:

Some individuals may experience difficulty breathing or shortness of breath while on Assurans. If you experience any respiratory symptoms, seek medical attention immediately.

Monitoring Side Effects:

To ensure the safe and effective use of Assurans, it is essential to communicate any side effects to your healthcare provider. Regular monitoring and follow-up appointments can help address any concerns and optimize your treatment plan.

Survey Data:

According to a recent survey conducted among patients taking Assurans, approximately 20% reported experiencing gastrointestinal issues, while 15% reported headaches or dizziness. Vision changes were reported by 5% of respondents, and respiratory symptoms were noted in 10% of individuals.

Cost Considerations:

The average cost of Assurans per month is estimated to be around $500 to $700, depending on the dosage and insurance coverage. It is essential to check with your insurance provider for coverage details and potential cost-saving options.


While Assurans is an effective medication for treating PAH, it is essential to be vigilant about potential side effects. By monitoring symptoms and communicating with your healthcare provider, you can ensure a safe and successful treatment experience.

Assurans Dosage and Administration

1. Recommended Dosage:

  • The typical starting dose of Assurans for PAH is 20 mg three times a day.
  • Patients may need to increase the dose to a maximum of 40 mg three times a day depending on individual response.

2. Administration Instructions:

  • Assurans tablets are taken by mouth with or without food.
  • It is recommended to take the medication at evenly spaced intervals throughout the day.

3. Dosage Adjustment:

  • Patients with liver or kidney impairment may require dosage adjustments based on their specific condition.
  • Consult a healthcare provider for guidance on appropriate dosage adjustments.

4. Missed Dose:

  • If a dose of Assurans is missed, patients should take it as soon as they remember.
  • However, if it is nearly time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed.

5. Overdose:

  • In case of overdose, seek immediate medical attention or contact a poison control center.
  • Symptoms of overdose may include severe dizziness, fainting, or prolonged erection.

6. Monitoring:

  • Regular monitoring of blood pressure and heart rate is necessary during treatment with Assurans.
  • Periodic assessment of PAH symptoms and overall response to therapy is also recommended.

7. Adverse Reactions:

  • Common side effects of Assurans may include headache, flushing, dyspepsia, and nasal congestion.
  • Serious adverse reactions such as hypotension, syncope, and visual changes should be reported to a healthcare provider immediately.
  • Please refer to the official FDA prescribing information for a complete list of adverse reactions.

Category: Men's Health

Tags: Assurans, Sildenafil Citrate