Theo-24 SR belongs to the group of anti-asthma pharmaceuticals that are used to treat obstructive respiratory diseases. It has a pronounced antispasmodic, vasodilating, bronchodilating, anti-asthma, cardiotonic effect.
Indications for use
- Bronchial asthma;
- Symptomatic treatment of bronchospasm of various etiologies (including those with chronic obstructive pulmonary diseases, chronic bronchitis, emphysema);
- Pulmonary hypertension;
- Pulmonary heart;
- Cheyne-Stokes-type respiratory disorder;
- Impaired cerebral circulation.
How to take Theo-24 SR?
Take this drug orally as directed by your doctor.
Do not crush or chew the tablets. The dosage is based on your medical condition, age, weight, lab tests and other drugs you may be using. To reduce your risk of side effects, your doctor may recommend that you start this drug at a low dose and gradually increase it.
Take these tablets regularly to get the best results. It’s recommended to take the tablets at the same time each day. Keep taking this drug even if you feel well. Do not increase your dose or stop taking it without consulting your doctor.
Do not take Theo-24 SR if you have:
- hypersensitivity to the drug (including other xanthine derivatives – caffeine, pentoxifylline, theobromine);
- peptic ulcer and 12 duodenal ulcer;
- gastritis with increased acidity;
- a recent history of gastrointestinal bleeding;
- severe arterial hyper- or hypotension;
- severe tachyarrhythmias;
- hemorrhagic stroke;
- retinal hemorrhage.
With caution: severe coronary insufficiency (acute phase of myocardial infarction, angina pectoris), widespread atherosclerosis of the vessels, frequent ventricular extrasystole, increased convulsive readiness, uncontrolled hypothyroidism (the possibility of cumulation) or thyrotoxicosis, prolonged hyperthermia, gastroesophageal reflux, prostatic hypertrophy, pregnancy, lactation, alive, hepatic and / or renal failure, gastric ulcer and 12 duodenal ulcer (history), children’s age.
- Nervous system: dizziness, headache, agitation, insomnia, anxiety, irritability, tremor;
- Heart: palpitations, tachycardia (including the fetus when a pregnant woman is taken in the third trimester), arrhythmias, decreased blood pressure, cardialgia, increased frequency of angina attacks;
- Digestive system: gastralgia, nausea, vomiting, gastroesophageal reflux, heartburn, exacerbation of peptic ulcer, diarrhea, with prolonged use – decreased appetite;
- Allergic reactions to the components of the drug: skin rash, itching, fever;
- Other: chest pain, tachypnea, flushing, albuminuria, hematuria, hypoglycemia, increased urine output, increased sweating.
Side effects decrease with a decrease in the dose of the drug.
Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including blood), gastrointestinal bleeding, tachypnea, facial flushing, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions. Severe poisoning can cause epileptoid seizures (especially in children without any precursors), metabolic acidosis, hypoxia, hyperglycemia decreased blood pressure, skeletal muscle necrosis, hypokalemia, confusion, renal failure with myoglobinuria.
Treatment: drug discontinuation, gastric lavage, use of activated charcoal, laxative drugs, intestinal lavage with a combination of polyethylene glycol and electrolytes, forced diuresis, hemodialysis (low efficiency, peritoneal dialysis is ineffective), symptomatic therapy (including metoclopramide and ondansetron – with vomiting).
Pregnancy and breastfeeding
The drug penetrates into breast milk, so it’s not recommended to use it during pregnancy.
During pregnancy, Theo-24 SR is used only if the expected benefit to the mother outweighs the possible risk to the fetus.
- The use of the drug increases the likelihood of side effects of GCS, ISS (hypernatremia), agents for general anesthesia (the risk of ventricular arrhythmias increases), agents that excite the central nervous system (increases neurotoxicity);
- Antidiarrheal drugs and enterosorbents reduce the absorption of theophylline;
- Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives, being inducers of microsomal oxidation, increase the clearance of the drug, which may require an increase in its dose;
- With simultaneous use with P450 inhibitors (including antibiotics of the macrolide group, lincomycin, allopurinol, cimetidine, fluoroquinolones), isoprenaline, enoxacin, disulfiram, recombinant interferon-alpha, methotrexate, mexiletine, a reduction in the dose of theophylline may be required;
- Theophylline enhances the action of beta-adrenostimulants and diuretics (including by increasing glomerular filtration), reduces the effectiveness of Li + and beta-blockers;
- Do not use this drug in conjunction with other xanthine derivatives. Caution should be exercised when taking the drug simultaneously with anticoagulants.